Myasthenia gravis is an autoimmune neuromuscular disease leading to fluctuating muscle weakness and fatiguability. It is an autoimmune disorder, in which weakness is caused by circulating antibodies that block acetylcholine receptors at the postsynaptic neuromuscular junction, inhibiting the stimulative effect of the neurotransmitter acetylcholine.

Myasthenia is treated medically with cholinesterase inhibitors or immunosuppressants, and, in selected cases, thymectomy. The disease incidence is 3–30 cases per million and rising as a result of increased awareness.Myasthenia gravis is a problem of autoimmune mediated decrease in number of acetylcholine receptors at neuromuscular junctions resulting in weakness & fatigability in skeltal muscles.Thymus is abnormal in about 75% 0f cases.

Whom can it affect?
• Females are affected more often than males
• Age of onset in females is during second to third decade
• Onset is after sixth decade in males
• 2 out of every 100000 people are affected by MG

Causes of MG:
• Genetic
• Immunological
• Thymus tumors or abnormal enlargement (hyperplasia)
• Stress (aggravating factor in existing cases of Myasthenia Gravis)

Symptoms of MG:
• Drooping eyelids (ptosis)
• Double vision (diplopia)
• Difficulty in speech, slurred speech
• Difficulty in swallowing
• Nasal sounding speech
• Weakness of neck muscles
• Weakness of arms and legs
• Symptoms are usually intermittent (i.e. come and go)
• Symptoms may disappear for weeks and may appear again, later
• Weakness tends to worsen as the day progresses and after prolonged activity

Principles of treatments

• Amapachana
  
• Deepan
  
• Panchakarma Therapies
  
• Anti-Vata+ anti Kapha Herbal medicines to reverse the disease process