Non-alcoholic fatty liver disease (NAFLD) is one cause of fatty liver changes, when fat is deposited (steatosis) in the liver when this is not due to excessive alcohol use.

It is related to insulin resistance and the metabolic syndrome, and may respond to treatments originally developed for other insulin-resistant states, such as weight loss, metformin and thiazolidinediones.

Non-alcoholic steatohepatitis (NASH) is the most extreme form of NAFLD, which is regarded as a major cause of cirrhosis of the liver of unknown cause.

In the study, presented at the International Liver Congress in Berlin, researchers analyzed data from three nationwide U.S. & World surveys conducted between 1988 and 2008, including responses from 39,500 adults.

The results showed that during the study period, the prevalence of non-alcoholic fatty liver disease doubled from 5.51% to 11%.

Researchers found during the first survey period from 1988-1994, 46.8% of all chronic liver disease was related to non-alcoholic fatty liver disease. But by 2005-2008, this proportion had risen to 75.1%.

In addition, the prevalence of diabetes and obesity, the two primary risk factors for non-alcoholic fatty liver disease, also rose steadily.

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